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. 2021 Jul 8;21:360. doi: 10.1186/s12935-021-02019-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — LINC00115 could bind to miR-30a. A Comparing the predicted results of LINC00115-targeted miRs from the miRcode and RNAInter databases, there were five intersecting miRs; B The expression heat map of 10 differentially expressed miRs on GSE48485, in which Y-axis represents miRs. The upper right histogram is the color order, and each rectangle corresponds to a sample expression value; C The binding sites between LINC00115 and miR-30a were analyzed by RNAInter database; D-F. LNC00115 could bind to miR-30a verified by dual luciferase reporter gene assay (D, vs the mimic-NC group, **p < 0.01), RNA pull-down assay (E, vs the Bio-miR-30a-mut group, **p < 0.01) and RIP assay (F, vs the IgG group, ***p < 0.001). Data in panel D were analyzed using the unpaired t test, and data in panels E–F were analyzed using one-way ANOVA and Tukey’s multiple comparison test. Repetitions = 3. The experiment was performed in triplicate and data were expressed as means ± standard deviation