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Systemic chronic active EBV infection involving the gastrointestinal tract: (a) Esophagus biopsy shows a polymorphic inflammatory infiltrate with a predominance of non-atypical small lymphocytes (H&E, ×60 and ×300); (b) The lymphoid infiltrate contains a predominance of CD3+ T-cells (×60); (c) Anti-CD20 immunostaining shows scattered reactive B-cells (×60); (d) EBV-encoded small RNA (EBER) in situ hybridization shows scattered positive cells (×60).
