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Extranodal NK/T-cell lymphoma, nasal type: (a) Nasal mucosa biopsy shows diffuse and expansive lymphoid infiltrate with necrosis (H&E, ×100 and ×400); (b) Ki67 immunostaining shows a high proliferative index (90%) of the atypical lymphoid infiltrate (×100); (c–e) The neoplastic cells are positive for CD3 (c, ×300) and CD56 (d, ×300), and negative for CD5 (e, ×300); (f) EBV-encoded small RNA (EBER) in situ hybridization is positive in almost all neoplastic lymphoid cells (×200).
