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Aggressive NK-cell leukemia: (a) Skin biopsy shows an intravascular atypical lymphoid infiltrate (H&E, ×50 and ×200); (b) EBV-encoded small RNA (EBER) in situ hybridization is positive in almost all neoplastic lymphoid cells; (c,d) Neoplastic lymphoid cells are positive for CD3 (c, ×300) and CD56 (d, ×300).
