Figure 2.

Regulation of fetal reprogramming and dedifferentiation in gastrointestinal tissues. Several processes including collagen deposition, IL-6, prostaglandin E2 (PGE2), retinoic acid synthesis, and bile acid receptor signaling have been reported to directly regulate Hippo/Yap-dependent fetal gene expression. Other processes mentioned and discussed in the text may promote dedifferentiation via alternative mechanisms. However, further investigation into the mechanisms regulating intestinal plasticity is required.