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. 2021 Jun 28;22(13):6974. doi: 10.3390/ijms22136974

Figure 3.

Figure 3

XA-induced DA release was blocked by NCS-486. A. Time course of the effect of 20 µM XA local application on DA release obtained in the absence or presence of 20 µM of the XA-receptor antagonist, NCS-486, as indicated. Data points are mean percentage ±SEM of the mean basal release of dopamine (mean of 8 × 20 min dialysate fractions before drug perfusion) and lines are interpolation between data points. The black horizontal bar indicates the period of local 20 min application by retro dialysis of 20 µM XA, co-infusion of XA 20 µM + NCS-486 20 µM or 20 µM of NCS-486 alone as indicated (n = 3 animals per group). Mean dopamine basal release (100%) was 130 ± 23 fmol/20 min. The infusion of XA alone induces a strong dopamine response, while the presence of NCS-486 completely blocked this dopamine increase. NCS-486 alone has no significant effect. ** p < 0.01 comparison with control before retro dialysis.