Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 25;13(13):3189. doi: 10.3390/cancers13133189

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Mitochondrial gene expression is enhanced in late stage multiple myeloma. (A) Fold-change in gene expression of TUFM and TFAM relative to GUSB in patients (MGUS n = 9; SMM n = 9; NDMM n = 18; RRMM n = 11). Data are presented as mean values ± SEM of technical triplicates. (B) High level of mitochondria-related genes identified by RNAseq analysis from the CoMMpass study (IA14); TUFM and COXII overexpression associate with shorter progression-free survival. (C,D) Heatmaps of canEvolve database analysis. (C) Gene-set enrichment analysis of the mitochondrial respiratory chain pathway; normal vs. NDMM, normal vs. RRMM. D. Gene-set enrichment analysis of the cytochrome c oxidase activity pathway; normal vs. NDMM, normal vs. RRMM. * p < 0.05.