Table 2.

Resume of cytotoxic effects registered in mammalian cell lines after exposure to different doses of AgNPs.

Coating and Size of AgNP	AgNP Dosage	Cell Type	Cytotoxic Effect	Reference
20 nm	10 to 100 μg/mL	CRL-2310	Dose-dependent effect in cell viability reduction. Viability of 98.76% after treatment with 10 μg/mL	[78]
10, 30 and 60 nm CIT, PEG, BSA	0 to 100 μg/mL	HaCaT	Alterations in metabolism and energy production related to ROS increase.	[57]
4.7 and 42 nm	5 to 2000 μg/mL	NHDF	ROS increase, reduction of cell viability dose and size-dependent.	[79]
13, 33 and 46 nm tannic acid	1 to 10 μg/mL	291.03C	Dose-dependent reduction in cell viability. Up regulation of TNF α	[80]
30 and 50 nm tannic acid and sodium borohydride	5 to 100 μg/mL	A431	Dose-dependent decrease of metabolic activity. Up regulation of TNF α	[82]
15.9 nm	12.1 μg/mL	A549	Modification in gene expression, increase in ROS production	[83]
15 nm	0 to 50 μg/mL	A549	Reduction in cell viability, increase in ROS dose dependent	[84]
10, 40 and 75 nm PVP, CIT	5 to 50 μg/mL	BEAS 2B	Toxicity only at 20 and 50 μg/mL of 10 nm AgNP, damage in DNA.	[85]
20 nm	1.95 μg/106 cells	C3A	Reduction in viability and cell function. Increase in IL-8 and TNF α	[86]
21.8 nm	0 to 1600 μg/mL	HepG2	Increase ROS production in dose dependent manner. Reduction of cell viability.	[87]
30 nm CIT, PEG	0 to 50 μg/mL	HepG2	Changes in expression of genes related to apoptosis and cell cycle.	[88]
200 nm	0 to 100 μg/mL	Caco 2	Significant toxic effects only at 100 μg/mL. Increase in IL-8 production.	[89]
20 and 40 nm peptide coated	5 to 100 μg/mL	Caco 2	Reduction of cell viability, increase in ROS, dose and size-dependent.	[90]