Table 2.
Exosomal RNAs involved in the development and progression in PaCa
| RNA Type | Molecules | Origin | Effects | Targets | Refs. |
|---|---|---|---|---|---|
| miRNA | miRNA-222 | TDEs |
Proliferation ↑ Invasion ↑ |
p27/Akt | [61] |
| miRNA-501-3p | TAMs |
Tumorigenesis ↑ Metastasis ↑ |
TGFBR3/ TGF-β | [62] | |
| miRNA-5703 | PSCs | Proliferation ↑ | CMTM4/PI3K/Akt | [63] | |
| miRNA-3607-3p | NK cells |
Proliferation ↓ Migration ↓ Invasion ↓ |
IL-26 | [64] | |
| miRNA-1231 | BM-MSCs |
Proliferation ↓ Migration ↓ Invasion ↓ |
Not mentioned | [65] | |
| miRNA-126-3p | BM-MSCs |
Proliferation ↓ Migration ↓ Invasion ↓ |
ADAM9 | [66] | |
| miRNA-27a | TDEs | Angiogenesis ↑ | BTG2 | [68] | |
| miRNA-10a-5p | CAFs |
Migration ↑ Invasion ↑ |
VDR | [71] | |
| miRNA-21 | CAFs |
Migration ↑ Invasion ↑ |
Not mentioned | [72] | |
| miRNA-221 | CAFs |
Migration ↑ Invasion ↑ |
NF-κ B/KRAS | [72] | |
| miRNA-21-5p | PSCs |
Proliferation ↑ Migration ↑ |
Not mentioned | [73] | |
| miRNA-451a | PSCs |
Proliferation ↑ Migration ↑ |
Not mentioned | [73] | |
| miRNA-125b-5p | TDEs |
Migration ↑ Invasion ↑ EMT ↑ |
MEK2/ERK2 | [85] | |
| miRNA-301a | TDEs |
Migration ↑ Invasion ↑ EMT ↑ |
PTEN/PI3Kγ | [86] | |
| miRNA-203 | TDEs | Immune Escape ↑ | TNF-α/IL-12/TLR4 | [94] | |
| miRNA-212-3p | TDEs | Immune Escape ↑ | RFXAP/ MHC II | [95] | |
| miRNA-210 | TDEs | GEM-resistance ↑ | mTOR | [99] | |
| miRNA-106b | CAFs | GEM-resistance ↑ | TP53INP1 | [100] | |
| miRNA-365 | TAMs | GEM-resistance ↑ | NTP/CDA | [101] | |
| miRNA-155 | TDEs | GEM-resistance ↑ | SOD/CAT/DCK | [103] | |
| miRNA-194-5p | TDEs | Radiotherapy-resistance ↑ | E2F3 | [105] | |
| lncRNA | UCA1 | TDEs | Angiogenesis ↑ | miRNA-96-5p/AMOTL2 | [69] |
| SBF2-AS1 | TAMs |
Migration ↑ Invasion ↑ Metastasis ↑ |
miRNA-122-5p/XIAP | [74] | |
| HULC | TAMs |
EMT ↑ Invasion ↑ Migration ↑ |
Not mentioned | [75] | |
| NONHSAT105177 | TDEs |
Proliferation ↓ Migration ↓ EMT ↓ |
Clusterin | [76] | |
| Sox2ot | TDEs |
Invasion ↑ Metastasis ↑ EMT ↑ |
miRNA-200 family/ Sox2 | [77] | |
| circRNA | PDE8A | TDEs | Invasion ↑ | miRNA-338/MACC1/MET | [78] |
| IARS | TDEs | Metastasis ↑ | HUVECs | [79] | |
| hsa_circ_0002130 | TDEs | Radiotherapy-resistance ↑ | Not mentioned | [106] |