Figure 4.

Expression of selected miRNAs in studied cell culture model (A–H). Variants differentiated in normoglycemic conditions and chronic hyperglycemia (HG) are colored in green and red, respectively.Variants of transient HG treatment applied during one stage of cell culture are marked with rhombuses with a black upper half and variants exposed to HG during two stages are denoted by rhombuses with a black lower half. Data are presented as mean ± SEM. Significant differences are marked by asterisks according to the p-value criteria: *—0.05 ≥ p > 0.01, **—0.01 ≥ p > 0.001, ***—p ≤ 0.001. Significant differences estimated in one-way ANOVA with a post-hoc Tukey test are marked by green or red asterisks.