Figure 9.

Schematic overview: (A) Major characteristics, cell functions, and methylation modes of the LGG types. (B) Cell-level view suggesting that aberrant DNA methylation shapes IDH mut gliomas into a developmental hierarchy while IDH-wt gliomas consist of multiple cellular states. The scheme was partly adapted from [98] on the basis of recent single-cell transcriptomic studies [66,67,99,100] and our mapping of single cell glioma signatures (Figure S11). See text.