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. 2021 Jun 28;13(13):3223. doi: 10.3390/cancers13133223

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Results of the analysis using the Encyclopaedia of DNA Elements (ENCODE) and FAL1 and ECM1 expression according to patients’ age. (A) The TFBS of JUND, c-JUN, and JUN-FOS in the promoter area of ECM1 and FAL1. (B) Expression of the transcriptional target genes of c-JUN according to ECM1 and FAL1 expression status in TCGA THCA. (C) Expression of the transcriptional target genes of JUND according to ECM1 and FAL1 expression status in TCGA THCA. (D) Selected target gene expressions were identified in GSE127083 RNA-seq dataset for K562 cells treated with JUND-targeted CRISPRi. (E) FAL1 expression status according to patients’ age (F) ECM1 expression status according to patients’ age. Abbreviations: JUND, junD proto-oncogene; AP-1, transcription factor subunit; JUN, jun proto-oncogene; FOS, fos proto-oncogene; TFBS, transcription factor-binding sites; TCGA, The Cancer Genome Atlas; THCA, thyroid carcinoma; E2F1, transcription factor E2F transcription factor 1; E2F2, transcription factor E2F transcription factor 2; VEGFA, vascular endothelial growth factor A; CCND1 Cyclin D1. Average values were compared using ANOVA, Student’s t-test. In the scatter plots, data are expressed as mean ± SD. All p-values are two-sided. * p < 0.01, ** p < 0.001.

Results of the analysis using the Encyclopaedia of DNA Elements (ENCODE) and FAL1 and ECM1 expression according to patients’ age. (A) The TFBS of JUND, c-JUN, and JUN-FOS in the promoter area of ECM1 and FAL1. (B) Expression of the transcriptional target genes of c-JUN according to ECM1 and FAL1 expression status in TCGA THCA. (C) Expression of the transcriptional target genes of JUND according to ECM1 and FAL1 expression status in TCGA THCA. (D) Selected target gene expressions were identified in GSE127083 RNA-seq dataset for K562 cells treated with JUND-targeted CRISPRi. (E) FAL1 expression status according to patients’ age (F) ECM1 expression status according to patients’ age. Abbreviations: JUND, junD proto-oncogene; AP-1, transcription factor subunit; JUN, jun proto-oncogene; FOS, fos proto-oncogene; TFBS, transcription factor-binding sites; TCGA, The Cancer Genome Atlas; THCA, thyroid carcinoma; E2F1, transcription factor E2F transcription factor 1; E2F2, transcription factor E2F transcription factor 2; VEGFA, vascular endothelial growth factor A; CCND1 Cyclin D1. Average values were compared using ANOVA, Student’s t-test. In the scatter plots, data are expressed as mean ± SD. All p-values are two-sided. * p < 0.01, ** p < 0.001.