Table 1.
Molecular features of TCGA THCA according to FAL1 expression status.
| Molecular Feature | FAL1 | p Value | |
|---|---|---|---|
| Low Expression n = 124 (%) |
High Expression n = 124 (%) |
||
| mRNA cluster number | |||
| 1 | 12 (9.8) | 59 (48.8) | <0.0001 † |
| 2 | 13 (10.7) | 22 (18.2) | |
| 3 | 32 (26.2) | 5 (4.1) | |
| 4 | 39 (32.0) | 8 (6.6) | |
| 5 | 26 (21.3) | 27 (22.3) | |
| miRNA cluster number | |||
| 1 | 2 (1.6) | 2 (1.6) | <0.0001 † |
| 2 | 48 (39.0) | 19 (15.4) | |
| 3 | 26 (21.1) | 7 (5.7) | |
| 4 | 16 (13.0) | 58 (47.2) | |
| 5 | 16 (13.0) | 19 (15.4) | |
| 6 | 15 (12.2) | 18 (14.6) | |
| RAS mutation | |||
| Absent | 122 (98.4) | 89 (72.4) | <0.0001 † |
| Present | 2 (1.6) | 34 (27.6) | |
| BRAF mutation | |||
| Absent | 31 (25.0) | 97 (78.9) | <0.0001 † |
| Present | 93 (75.0) | 26 (21.1) | |
| TERT promoter mutation | |||
| Absent | 88 (87.1) | 81 (89.0) | 0.688 † |
| Present | 13 (12.9) | 10 (11.0) | |
| RAS/RAF score | −0.67 ± 0.49 | 0.21 ± 0.67 | <0.0001 * |
| ERK score | 11.37 ± 16.27 | 2.14 ± 20.26 | 0.001 * |
| Differentiation score | −0.49 ± 0.99 | 0.54 ± 1.08 | <0.0001 * |
| Akt pT308 | −0.02 ± 0.64 | 0.06 ± 0.47 | 0.275 * |
| Akt pS473 | −0.02 ± 0.47 | 0.09 ± 0.34 | 0.047 * |
TCGA, The Cancer Genome Atlas; THCA, thyroid carcinoma. † p values calculated by Student’s t test; * p values calculated by chi-square test or linear-by-linear association.