Table 2.
Molecular features of TCGA THCA according to ECM1 expression status.
| Molecular Feature | ECM1 | p Value | |
|---|---|---|---|
| Low Expression n = 124 (%) |
High Expression n = 124 (%) |
||
| mRNA cluster number | |||
| 1 | 58 (47.9) | 51 (43.2) | 0.190 † |
| 2 | 7 (5.8) | 21 (17.8) | |
| 3 | 36 (29.8) | 5 (4.2) | |
| 4 | 5 (4.1) | 14 (11.9) | |
| 5 | 15 (12.4) | 27 (22.9) | |
| miRNA cluster number | |||
| 1 | 3 (2.5) | 3 (2.4) | 0.796 † |
| 2 | 16 (13.1) | 22 (17.9) | |
| 3 | 24 (19.7) | 11 (8.9) | |
| 4 | 46 (37.7) | 51 (41.5) | |
| 5 | 19 (15.6) | 21 (17.1) | |
| 6 | 14 (11.5) | 15 (12.2) | |
| RAS mutation | |||
| Absent | 117 (95.1) | 90 (73.2) | <0.0001 † |
| Present | 6 (4.9) | 33 (26.8) | |
| BRAF mutation | |||
| Absent | 71 (57.7) | 92 (74.8) | 0.005 † |
| Present | 52 (42.3) | 31 (25.2) | |
| TERT promoter mutation | |||
| Absent | 91 (95.8) | 78 (84.8) | 0.011 † |
| Present | 4 (4.2) | 14 (15.2) | |
| RAS/RAF score | 0.01 ± 0.81 | 0.07 ± 0.68 | 0.533 * |
| ERK score | −5.25 ± 23.26 | 4.92 ± 19.35 | 0.001 * |
| Differentiation score | 0.32 ± 1.37 | 0.39 ± 1.00 | 0.674 * |
| Akt pT308 | 0.09 ± 0.54 | 0.06 ± 0.35 | 0.691 * |
| Akt pS473 | 0.14 ± 0.66 | 0.01 ± 0.46 | 0.122 * |
TCGA, The Cancer Genome Atlas; THCA, thyroid carcinoma. † p values calculated by Student’s t test; * p values calculated by chi-square test or linear-by-linear association.