TABLE 3.
Risk of a first venous thrombosis associated with D‐dimer levels and TG stratified by types of thrombosis
| Crude OR (95% CI) |
OR a All VT (95% CI) |
OR DVT a (95% CI) |
OR PE±DVT a (95% CI) |
OR provoked a (95% CI) |
OR unprovoked a (95% CI) |
|
|---|---|---|---|---|---|---|
| D‐dimer | ||||||
| ≤P90 | 1(ref) | 1(ref) | 1 (ref) | 1 (ref) | 1(ref) | 1(ref) |
| >P90 | 2.4 (1.5‐3.9) | 2.1 (1.3‐3.4) | 2.8 (1.6‐5.0) | 1.6 (0.9‐3.1) | 1.9 (1.0‐3.6) | 2.3 (1.3‐4.3) |
| TG | ||||||
| Peak thrombin | ||||||
| ≤P90 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) |
| >P90 | 2.7 (1.7‐4.4) | 3.7 (2.2‐6.2) | 3.1 (1.6‐5.8) | 4.3 (2.3‐8.2) | 2.7 (1.4‐5.2) | 4.9 (2.7‐9.2) |
| Time to peak | ||||||
| ≥P10 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) |
| <P10 | 1.9 (1.2‐3.2) | 2.4 (1.4‐4.2) | 2.4 (1.2‐4.6) | 2.2 (1.1‐4.3) | 1.6 (0.8‐3.4) | 3.2 (1.7‐6.0) |
| Lag time | ||||||
| ≥P10 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) |
| <P10 | 0.7 (0.4‐1.4) | 0.7 (0.4‐1.3) | 1.1 (0.5‐2.3) | 0.4 (0.1‐1.0) | 0.6 (0.2‐1.4) | 0.8 (0.4‐1.8) |
| ETP | ||||||
| ≤P90 | 1(ref) | 1(ref) | 1(ref) | 1(ref) | 1(ref) | 1(ref) |
| >P90 | 3.8 (2.4‐6.0) | 3.8 (2.3‐6.1) | 3.3 (1.9‐5.8) | 4.4 (2.4‐7.8) | 2.8 (1.6‐5.1) | 4.9 (2.8‐8.6) |
| Velocity index | ||||||
| ≤P90 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) |
| >P90 | 2.4 (1.5‐3.8) | 4.3 (2.4‐7.9) | 3.2 (1.6‐6.5) | 5.5 (2.7‐11.3) | 4.0 (2.0‐8.2) | 4.4 (2.2‐8.9) |
Cutoff values: D‐dimer, 1410 ng/mL (P90); peak thrombin, 154 nM (P90); time to peak, 13 min (P10); lag time, 7 min (P10); ETP, 1519 nM.min (P90); velocity index, 29 nM.min−1 (P90).
Abbreviations: CAT, calibrated automated thrombography; CI, confidence interval; DVT, deep vein thrombosis; ETP, endogenous thrombin potential; PE, pulmonary embolism; TG, thrombin generation; VT, venous thrombosis.
a
Adjusted for age, sex, study center, body mass index, and smoking.