TABLE 4.
Risk of venous thrombosis associated with D‐dimer and TG parameters (quartile)
| Percentile |
Patients N = 215 |
Controls N = 358 |
OR a (CI95) |
|---|---|---|---|
| D‐dimer | |||
| ≤P25 | 16 | 89 | 1 (ref) |
| P25‐P50 | 24 | 90 | 1.5 (0.8‐3.2) |
| P50‐P75 | 62 | 90 | 4.2 (2.2‐8.2) |
| >P75 | 113 | 89 | 7.7 (4.0‐14.8) |
| Thrombinoscope TG (CAT) | |||
| Peak thrombin | |||
| ≤P25 | 15 | 89 | 1 (ref) |
| P25‐P50 | 33 | 90 | 2.2 (1.1‐4.4) |
| P50‐P75 | 72 | 90 | 4.3 (2.2‐8.4) |
| >P75 | 95 | 89 | 7.8 (4.0‐15.0) |
| Time to peak | |||
| ≤P25 | 72 | 90 | 2.0 (1.2‐3.3) |
| P25‐P50 | 55 | 90 | 1.2 (0.7‐2.1) |
| P50‐P75 | 45 | 92 | 0.9 (0.5‐1.5) |
| >P75 | 43 | 86 | 1 (ref) |
| Lag time | |||
| ≤P25 | 55 | 89 | 0.8 (0.5‐1.4) |
| P25‐P50 | 54 | 90 | 0.9 (0.5‐1.5) |
| P50‐P75 | 54 | 92 | 0.9 (0.5‐1.4) |
| >P75 | 52 | 87 | 1 (ref) |
| ETP | |||
| ≤P25 | 10 | 89 | 1 (ref) |
| P25‐P50 | 42 | 90 | 3.9 (1.9‐8.3) |
| P50‐P75 | 58 | 90 | 4.9 (2.3‐10.4) |
| >P75 | 105 | 89 | 9.1 (4.4‐18.9) |
| Velocity index | |||
| ≤P25 | 13 | 89 | 1 (ref) |
| P25‐P50 | 44 | 90 | 3.7 (1.8‐7.7) |
| P50‐P75 | 61 | 90 | 4.8 (2.4‐9.7) |
| >P75 | 97 | 89 | 11.5 (5.7‐23.3) |
Cutoff values: D‐dimer: P25 338.8 ng/mL, P50 516.3 ng/mL, P75 848.7 ng/mL; peak thrombin: P25 72.1 nM, P50 94.8 nM, P75 125.0 nM; time to peak: P25 14.1 min, P50 15.7 min, P75 17.0 min; lag time: P25 7.6 min, P50 8.5 min, P75 9.7 min; ETP: P25 942.7 nM.min, P50 1174.7 nM.min, P75 1381.4 nM.min; velocity index: P25 9.3 nM.min−1, P50 13.5 nM.min−1, P75: 19.3 nM.min−1.
Abbreviations: CAT, calibrated automated thrombography; CI, confidence interval; ETP, endogenous thrombin potential; OR, odds ratio; TG, thrombin generation.
a
Adjusted for age, sex, study center, body mass index, and smoking for D‐dimer and TG parameters.