TABLE 6.
Risk of venous thrombosis of combined analysis of TG parameters (peak and ETP), D‐dimer and prothrombotic mutations
| D‐dimer and TG parameters | Prothrombotic mutations |
Patients N=215 |
Controls N=358 |
OR a (95% CI) |
|---|---|---|---|---|
| D‐dimer | ||||
| − | − | 92 | 254 | 1(ref) |
| − | + | 10 | 14 | 2.0 (0.8‐4.7) |
| + | − | 99 | 83 | 3.3 (2.2‐5.0) |
| + | + | 14 | 6 | 5.3 (1.9‐14.6) |
| Peak | ||||
| − | − | 106 | 256 | 1 (ref) |
| − | + | 14 | 13 | 2.5 (1.1‐5.6) |
| + | − | 85 | 82 | 3.3 (2.2‐4.9) |
| + | + | 10 | 7 | 3.8 (1.3‐11.0) |
| ETP | ||||
| − | − | 100 | 255 | 1 (ref) |
| − | + | 10 | 14 | 1.7 (0.7‐4.0) |
| + | − | 91 | 83 | 2.7 (1.8‐4.0) |
| + | + | 14 | 6 | 5.5 (2.0‐15.5) |
Prothrombotic mutations included prothrombin G20210A mutation and factor V Leiden mutation. D‐dimer, ETP and peak are dichotomized at the 75th percentile measured in controls.
Abbreviations: CI, confidence interval; ETP, endogenous thrombin potential;OR, odds ratio; TG, thrombin generation.
a
Adjusted for age, sex, study center, body mass index, and smoking.