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. 2021 Jul 9;24(8):102823. doi: 10.1016/j.isci.2021.102823

Table 1.

Biomarker panel identified from multi-omics analysis

SRNO Proteins Mean decrease accuracy AUC p-val. (FDR corrected) Log 2 FC (COV2+ vs. COV2-)
1 MX1 0.008728 0.885 2.64E-09 6.038
2 WARS 0.007161 0.94 2.57E-08 4.658
3 PFN1 0.003191 0.885 0.0002 2.778
4 CPSF6 0.003086 0.8125 0.000185 -4.375
5 S100P 0.002588 0.735 0.000496 2.453
6 TFF3 0.00258 0.8725 4.75E-05 5.049
7 SERPINC1 0.002424 0.7375 0.014789 0.834
8 HBD 0.002374 0.835 3.82E-05 -5.107
9 HEBP2 0.002326 0.7375 2.63E-05 5.385
10 SRP14 0.00227 0.7725 0.000863 4.106
11 PGK1 0.002233 0.9175 5.55E-08 2.961
12 S100A12 0.00223 0.82 0.000301 2.089
13 HSP90AB1 0.002114 0.8625 9.15E-06 1.964
14 GDI2 0.00206 0.8825 6.41E-06 2.950
15 ARHGAP1 0.002021 0.795 0.000285 3.691
16 BPIFB1 0.001944 0.86 7.43E-05 1.518
17 RUVBL1 0.001919 0.7725 0.000568 3.433
18 HNRNPA1 0.001867 0.79 0.001001 1.585
19 OPRPN 0.001803 0.78 0.004863 -2.078
20 ACTN4 0.001755 0.9275 4.08E-06 3.116
21 FARSA 0.001703 0.8025 0.000251 3.813
22 DCD 0.001617 0.6675 0.032855 2.365
23 IDH1 0.001564 0.74 0.00246 2.748
24 PSME2 0.001474 0.7425 0.022482 1.186
25 CAPZB 0.001452 0.79 0.001087 2.737
26 TYMP 0.001372 0.7875 0.010334 1.540
27 PKM 0.001337 0.8525 9.5E-05 2.385
28 EEF1A1 0.001288 0.78 0.001064 2.096
29 MYL6 0.001211 0.805 0.000254 -3.703
30 S100A6 0.001197 0.8325 9.01E-05 3.629
Metabolites Mean decrease accuracy AUC p-val. (FDR corrected) Log 2 FC (COV2+ vs. COV2-)
1 C00978 0.021992 0.99 2.89E-07 -2.096
2 C14774 0.017813 0.985 4.36E-11 -1.129
3 CE4969 0.009625 0.9475 4.03E-05 -0.944
4 C08261 0.009547 0.9075 1.03E-07 2.758
5 C01747 0.009199 0.855 0.001579 -0.848
6 C04540 0.008258 0.9125 0.001682 -1.632
7 C00135 0.008031 0.855 9.54E-05 2.310
8 HMDB0011719 0.007559 0.82 7.39E-05 1.470
9 C00864 0.007174 0.9 4.66E-07 2.104
10 C00555 0.006792 0.8625 0.000207 -1.355
11 C04500 0.006586 0.855 1.67E-05 -2.552
12 C06135 0.006539 0.885 8.24E-05 -1.280
13 CE2176 0.006415 0.8025 0.000304 1.198
14 C03017 0.006253 0.8525 0.000253 1.873
15 C04277 0.006133 0.85 0.00947 -0.857
16 C06186 0.005733 0.8375 0.000273 1.041
17 C14875 0.005561 0.835 0.013234 -0.478
18 tymsf 0.005265 0.82 0.004302 1.827
19 C01194 0.005201 0.8825 9E-06 1.694
20 prgnlones 0.004341 0.755 0.003275 -0.781
21 C03764 0.003972 0.84 0.000269 -0.966
22 C06078 0.003862 0.805 0.006341 -1.373
23 C19670 0.003857 0.8775 6.61E-05 1.918
24 C03758 0.003796 0.73 0.006803 1.549
25 C01879 0.003592 0.86 8.34E-05 -1.148
26 C06536 0.003494 0.83 0.000431 1.059
27 C03210 0.003324 0.8375 0.000301 -1.135
28 C16121 0.003144 0.8275 0.000837 -0.764
29 C04453 0.003088 0.7875 0.006481 -0.930
30 C01789 0.002887 0.685 0.002895 -0.839
Metaproteins Mean decrease accuracy AUC p-val. (FDR corrected) Log 2 FC (COV2+ vs. COV2-)
1 Proteobacteria:Burkholderiales:Burkholderia:GEGGEHGDGGADTAAQNGDR 0.033543 1 4.46E-29 19.093
2 Actinobacteria:Streptomycetales:Streptomyces:LGPMDFYGR 0.027812 1 5.28E-38 -20.577
3 Firmicutes:Bacillales:Lysinibacillus:LLLHVAGELALK 0.026731 1 2.42E-38 -20.390
4 Actinobacteria:Corynebacteriales:Corynebacteriales:GIGLLQADLLVVNK 0.02583 1 4.92E-39 -21.465
5 Firmicutes:Lactobacillales:Lactobacillus salivarius:VELSPIIIK 0.025604 1 2.9E-38 -23.767
6 ::Bacteria:IQVLTQAR 0.025283 1 2.45E-33 17.135
7 ::Bacteria:ALQATGLK 0.025233 1 4.33E-30 17.344
8 ::Bacteria:IALIGRPNVGK 0.024892 1 3.11E-41 -18.958
9 Proteobacteria:Desulfuromonadales:Geobacter:LIIAGGGTGGHLFPGIAIADEFLAR 0.024735 1 2.09E-25 22.290
10 ::Bacteria:LAALGLSLK 0.024362 1 7.76E-37 -19.295
11 Firmicutes:Bacillales:Bacillus subtilis:AAANPVTQQQPDILP 0.02414 1 1.25E-67 -32.198
12 ::Bacteria:YSTAGAR 0.022161 0.994 1.32E-35 -19.192
13 Proteobacteria:Desulfobacterales:Desulfatibacillum:DQEGQDVLIFIDNIFR 0.022079 0.994 2.93E-36 16.925
14 Firmicutes:Bacillales:Bacillus subtilis:QINLTITVIK 0.021523 0.994 4.42E-27 21.421
15 ::Bacteria:TEDMLPILEK 0.020414 0.994 3.16E-20 25.728
16 Proteobacteria:Vibrionales:Aliivibrio:RPLLLGIAK 0.018362 0.994 9.09E-28 19.575
17 Proteobacteria:Enterobacterales:Klebsiella pneumoniae:VAVLXAAGGIQALALLLK 0.017897 0.982 2.98E-26 18.305
18 Firmicutes:Natranaerobiales:Natranaerobius:IEEAGGDVEIK 0.017875 0.982 4.61E-20 -21.371
19 Firmicutes:Lactobacillales:Lactobacillus plantarum:GIDHGMTATALDAAAAMIAELGDGQVASGMVIGR 0.01782 0.982 4.08E-30 28.118
20 Proteobacteria:Pasteurellales:[Mannheimia] succiniciproducens:SVTDQDSK 0.01747 0.982 1.64E-42 17.170
21 Proteobacteria::Proteobacteria:LAVAGRPNVGK 0.017045 0.975 2.6E-38 -17.955
22 Tenericutes:Mycoplasmatales:Mycoplasma:NQLIRPK 0.016163 0.975 1.28E-26 24.527
23 Tenericutes:Mycoplasmatales:Mycoplasma genitalium:IEPNINLK 0.016142 0.975 4.79E-21 19.168
24 Proteobacteria:Rickettsiales:Rickettsia bellii:ILIILSIILCSLFTK 0.015536 0.975 2.03E-36 20.833
25 Bacteroidetes:Bacteroidetes Order II. Incertae sedis:Salinibacter ruber:EVGCCSIESMNDAR 0.015518 0.962 1.32E-35 19.985
26 Tenericutes:Mycoplasmatales:Mycoplasma:VIGILDSNSNPDAVDFGIPANDDSAK 0.014336 0.961 5.69E-28 19.027
27 Firmicutes::Firmicutes:ADDNAEHLFK 0.01373 0.958 3.09E-27 17.031
28 Proteobacteria:Enterobacterales:Enterobacterales:LLNLPLQVLVK 0.012895 0.956 1.53E-31 19.306
29 Firmicutes:Bacillales:Bacillales:VAVTAGASTPTPIVK 0.01284 0.954 7.75E-32 17.649
30 Tenericutes:Mycoplasmatales:Ureaplasma:VLIIGKPNVGK 0.010885 0.951 5.48E-31 18.380
31 Tenericutes:Mycoplasmatales:Mycoplasma penetrans:DFNCNNVVLVLNK 0.005724 0.89 0.000116 2.817