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. 2021 Jun 23;22(13):6726. doi: 10.3390/ijms22136726

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Knockdown of FRMD5 affects chemoresistance of TPC1 and BCPAP cells. (A) MTS-based analysis of FRMD5-deficient TPC1 and BCPAP cells exposed to doxorubicin (DOX) for 24 h. (B) Representative confocal microscopy images display intracellular DOX accumulation (red signal) in fluorescently labeled (fluorescein isothiocyanate (FITC)-conjugated phalloidin; green signal) cells. Images were recorded using 63×/1.4 oil DIC M27 lens. Cells treated with non-targeting siRNA (siNEG) were used as a control. Graphical data are presented as mean ± SD. ** p < 0.001; *** p < 0.0001.