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. 2021 Jun 23;22(13):6726. doi: 10.3390/ijms22136726

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Bubble plots of significantly enriched Gene Ontology (GO) terms for the FRMD5-depleted TPC1 (top panel) and BCPAP (bottom panel) cells after term similarity reduction. Terms with adjusted p-value on the PHRED scale higher than 4 (TPC1) and 5 (BCPAP) are annotated. The area of the circles is proportional to the number of genes assigned to the term in the analysis. The z-score (horizontal axis) indicates whether the given term is more likely to be up- or downregulated. The threshold indicates the adjusted p < 0.05.