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Activation of mAChRs and nAChRs enhances IL-6 release and immunoglobulin class switching from IgM to IgG in Daudi cells. Cooperative activation of mAChRs and TLR2 promotes the production of the IL-6 responsible for B cell maturation. In Daudi cells, this leads to class switching from IgM to IgG. Signals from nAChRs are important for activating the MyD88 and Mal/TIRAP pathways, which in turn increases the production and release of IL-6.
