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. 2021 Jun 22;22(13):6678. doi: 10.3390/ijms22136678

Figure 1.

Figure 1

Polymorphisms in ABCG2 protein sequence associated with pediatric-onset hyperuricemia and early-onset gout. Schematic overview of the ABCG2 domain structure consisting of a nucleotide-binding domain (light green, NBD) and a transmembrane domain (light brown, TMD) modified from [69]. Single membrane-spanning α-helices (TM1–6) were structured according to the information of published protein sequences (NCBI accession number: NP_001335914.1). The catalytic site for ATP hydrolysis is formed by the sequence motifs Walker A, Q-loop, Walker B, and H-loop of one monomer, and the c-signature and D-loop from the other monomer. Cysteine bridge forming residues and N-acetylation sites within extracellular loop 3 (EL3) are marked in grey. SNPs involved in pediatric-onset hyperuricemia and early-onset of gout published in recent seminal publications are highlighted in different colors (yellow, dark blue, and purple).