Figure 1.

Potential mechanism of REG I and REG IV signaling. Upon stimulation from exogenous growth factors or cytokines, REG I/REG IV bind to their putative receptors and subsequently activate or transactivate several signaling cascades, serving as mitogenic, antiapoptotic and/or angiogenic factors in the pathogenesis of various pathological conditions. EXTL3, exostoses-like gene 3; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; STAT3, signal transducer and activator of transcription 3; MZF1, myeloid zinc finger 1; RTEF1, related transcriptional enhancer factor-1; HLTF, helicase-like transcription factor; bFGF, basic fibroblast growth factor; HGF, hepatocyte growth factor; AP1, activator protein-1; EGFR, epidermal growth factor receptor; GSK-3β, glycogen synthase kinase 3β; TCF4, T-cell factor 4.