Table 2.
Characteristics of DS and age-matched control study population used to measure serum iron, ferritin, hepcidine, IL-6 and TREM2.
| Characteristic | Young Controls (YC) | Young DS (YDS) |
Old Controls (OC) |
Old DS (ODS) |
ANOVA Table | R2 | p-Value | p-Value Summary |
|---|---|---|---|---|---|---|---|---|
| Male + Females | N = 25 | N = 23 | N = 25 | N = 24 | F (DFn, DFd) | |||
| Age (years) | 40 ± 10 | 30 ± 10 | 50 ± 27 | 41 ± 25 | ||||
| Iron Parameter | ||||||||
| Serum iron (μmol/L) | 25.07 ± 5.06 | 19.11 ± 4.5 | 20.18 ± 7.2 | 13.92 ± 7.4 | 32.47 | 0.4985 | p < 0.0001 | **** |
| Serum Ferritin (μg/L) | 216.9 ± 171.1 | 122.56 ± 10.4 | 211.43 ± 45.5 | 139.83 ± 85.7 | 13.64 | 0.3198 | p < 0.0001 | **** |
| Serum Hepcidin (µg/L) | 23.89 ± 19.1 | 376.36 ± 475.4 | 26.56 ± 16.1 | 241.02 ± 430.5 | 18.09 | 0.35 | p < 0.0001 | **** |
| Inflammatory Parameter | ||||||||
| Serum IL-6 (µg/L) |
52.62 ± 21.01 | 244.29 ± 144.4 | 76.55 ± 31.4 | 343.14 ± 320.1 | 55.78 | 0.6307 | p < 0.0001 | **** |
| SerumTREM2 (pg/mL) |
1190.91 ± 150.2 | 894.30 ± 201.52 | 796.26 ± 147.65 | 562.79 ± 112.75 | 22.22 | 0.4807 | p < 0.0001 | **** |
Data are expressed as number of patients, mean ± SD. Probability values (p) denote differences between control and DS groups. One-way ANOVA that compared between groups, followed by Kruskal–Wallis or Bartlett’s test (corrected), was used that compared to age between groups, followed by Mann–Whitney test. **** p < 0.0001.