Skip to main content
. 2021 Jun 30;10(13):2937. doi: 10.3390/jcm10132937

Table 2.

Subchondral trabecular bone relative area (BA/TA) values in femoral heads from patients with OA measured in micro-CT before and after embedding of the MSC-Scaffold (MSCS), the percentage point changes in BA/TA values, the calculated corresponding subchondral trabecular bone densities ρB, and subchondral trabecular bone compressive strength S, before and after embedding of the MSC-Scaffold, and changes in subchondral trabecular bone densities ρB and subchondral trabecular bone compressive strength S; * spatial extent of subchondral trabecular bone densification due to the MSC-Scaffold prototype initial embedding [mm].

Patient No. Levels Below Reference Plane [mm] Mean ± SD
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0
1 BA/TA before MSCS embedding [%] 58.4 56.1 57.3 58.4 57.3 56.5 57.2 56.9 57.9 57.3 ± 0.8
BA/TA after MSCS embedding [%] 83.0 72.2 72.1 68.8 68.5 67.1 62.3 62.3 62.4
Change in BA/TA [%] 24.7 16.1 14.8 10.4 11.2 10.6 5.0 * 5.4 4.5
ρB before MSCS embedding [g/cm3] 1.50 1.48 1.49 1.50 1.49 1.48 1.49 1.48 1.49 1.49 ± 0.01
ρB after MSCS embedding [g/cm3] 1.71 1.61 1.61 1.58 1.58 1.57 1.53 1.53 1.53
ρB relative change [%] 14.3 9.0 8.3 5.6 6.3 6.1 2.9 3.1 2.5
S before MSCS embedding [MPa] 28.7 26.7 27.8 28.7 27.8 27.1 27.7 27.4 28.3 27.8 ± 0.7
S after MSCS embedding [MPa] 54.1 42.0 41.9 38.5 38.3 36.9 32.2 32.3 32.4
S relative change [%] 88.6 57.5 51.0 34.3 37.7 36.3 16.3 17.8 14.3
2 BA/TA before MSCS embedding [%] 55.1 54.1 52.0 53.2 52.2 52.0 51.9 52.7 52.8 52.9 ± 1.1
BA/TA after MSCS embedding [%] 79.7 66.1 65.2 59.3 55.9 53.5 53.2 54.8 52.9
Change in BA/TA [%] 24.6 12.0 13.2 6.0 3.7 * 1.4 1.3 2.1 0.1
ρB before MSCS embedding [g/cm3] 1.47 1.46 1.44 1.45 1.44 1.44 1.44 1.45 1.45 1.45 ± 0.01
ρB after MSCS embedding [g/cm3] 1.68 1.56 1.55 1.50 1.47 1.45 1.45 1.47 1.45
ρB relative change [%] 14.4 6.9 7.5 3.3 1.8 0.6 0.6 1.5 0.1
S before MSCS embedding [MPa] 25.9 25.0 23.3 24.3 23.5 23.3 23.2 23.8 23.9 24.0 ± 0.9
S after MSCS embedding [MPa] 50.3 35.9 35.0 29.5 26.5 24.5 24.3 25.6 24.1
S relative change [%] 94.3 43.2 50.1 21.3 12.9 5.0 4.5 7.3 0.5
3 BA/TA before MSCS embedding [%] 40.3 41.9 39.6 40.7 38.7 41.7 41.0 41.4 39.9 40.6 ± 1.0
BA/TA after MSCS embedding [%] 62.9 58.1 55.9 52.6 48.5 42.8 42.1 42.0 42.6
Change in BA/TA [%] 22.6 16.2 16.3 11.9 9.8 * 1.1 1.1 0.6 2.8
ρB before MSCS embedding [g/cm3] 1.34 1.36 1.34 1.35 1.33 1.35 1.35 1.35 1.34 1.34 ± 0.01
ρB after MSCS embedding [g/cm3] 1.53 1.49 1.47 1.45 1.41 1.36 1.36 1.36 1.36
ρB relative change [%] 14.0 9.9 10.0 7.7 6.1 0.4 0.9 0.6 1.6
S before MSCS embedding [MPa] 14.7 15.8 14.2 15.0 13.7 15.7 15.2 15.4 14.5 14.9 ± 0.7
S after MSCS embedding [MPa] 32.8 28.5 26.5 23.8 20.6 16.4 15.9 15.9 16.3
S relative change [%] 122.7 80.2 86.2 58.9 49.9 4.8 4.8 4.8 12.8
4 BA/TA before MSCS embedding [%] 49.7 50.0 52.2 54.0 53.1 51.9 51.4 50.9 49.9 51.4 ± 1.5
BA/TA after MSCS embedding [%] 67.9 65.0 64.7 59.0 57.4 55.3 55.0 53.7 53.9
Change in BA/TA [%] 18.2 15.0 12.5 4.9 * 4.3 3.4 3.6 2.8 4.0
ρB before MSCS embedding [g/cm3] 1.42 1.43 1.44 1.46 1.45 1.44 1.44 1.43 1.42 1.44 ± 0.01
ρB after MSCS embedding [g/cm3] 1.58 1.55 1.55 1.50 1.49 1.47 1.47 1.46 1.46
ρB relative change [%] 11.1 8.8 7.4 2.8 2.7 2.0 2.3 1.9 2.5
S before MSCS embedding [MPa] 21.5 21.8 23.5 25.0 24.2 23.2 22.8 22.4 21.6 22.9 ± 1.2
S after MSCS embedding [MPa] 37.7 34.9 34.5 29.2 27.8 26.0 25.8 24.7 24.8
S relative change [%] 75.3 60.3 47.1 17.1 15.1 12.0 13.0 10.2 14.9