Table 1.

Top 10 genes/GO terms in each cluster.

Cluster 1	Metabolism	GO Description	Top Gene	LogFC	adj. p-Value
	GO:0044255	Cellular lipid Metabolic process	Lipa	1.880428797	8.3778 × 10−265
	GO:0006629	Lipid metabolic process	Lima1	1.386559217	4.9641 × 10−287
	GO:0055114	oxidation-reduction process	P4ha1	1.216435527	4.0584 × 10−292
	GO:0032787	monocarboxylic acid metabolic process	Idh1	1.584898068	1.4915 × 10−241
	GO:0044242	cellular lipid catabolic process	Asah1	0.963340936	1.8342 × 10−167
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Il1rap	2.253245162	4.1379 × 10−303
	GO:0008610	lipid biosynthetic process	Serinc1	0.986106666	7.161 × 10−242
	GO:0008610	lipid biosynthetic process	Serinc1	0.986106666	7.161 × 10−242
	GO:0072329	monocarboxylic acid catabolic process	Ilvbl	2.185676922	1.048 × 10−151
	GO:0034389	lipid droplet organization	Sqle	0.920963676	4.2693 × 10−134
	GO:0044281	small molecule metabolic process	Cd44	0.996198493	5.32 × 10−285
Cluster 2	Immune	GO Description	Top Gene	logFC	adj. p-Value
	GO:0006952	defense response	Rtp4	4.132592871	1.8172 × 10−298
	GO:0051707	response to other organism	Usp18	6.2573426	1.7065 × 10−301
	GO:0043207	response to external biotic stimulus	Stat1	2.589408409	1.0021 × 10−269
	GO:0002376	immune system process	Ifi44	6.77996421	8.9746 × 10−266
	GO:0009607	response to biotic stimulus	Mlkl	4.440672777	7.6562 × 10−261
	GO:0006955	immune response	Cyba	6.401161196	2.3696 × 10−247
	GO:0051704	multi-organism process	Ifit2	2.868875789	7.9652 × 10−245
	GO:0009605	response to external stimulus	Gbp3	4.860447879	4.3027 × 10−236
	GO:0009615	response to virus	Oasl2	7.648377266	2.6227 × 10−227
	GO:0098542	defense response to other organism	Irgm2	4.930420913	4.1127 × 10−205
Cluster 3	Development	GO Description	Top Gene	logFC	adj. p-Value
	GO:0032502	developmental process	Slc6a17	−3.493587034	1.5326 × 10−295
	GO:0048869	cellular developmental process	Kazald1	−4.33489428	1.468 × 10−281
	GO:0051239	regulation of multicellular organismal process	Fam19a5	−4.123121971	4.1061 × 10−272
	GO:0032501	multicellular organismal process	Plxnb1	−4.447505569	3.2518 × 10−270
	GO:0050793	regulation of developmental process	Tenm3	−7.891281718	2.4011 × 10−266
	GO:0009653	anatomical structure morphogenesis	Jag1	−3.608377716	3.508 × 10−228
	GO:2000026	regulation of multicellular organismal development	Prdm16	−3.568565321	9.015 × 10−253
	GO:0051094	positive regulation of developmental process	P2rx7	−6.008024776	1.4826 × 10−187
	GO:0007155	cell adhesion	Sele	−5.033733739	4.4538 × 10−253
	GO:0022610	biological adhesion	Col12a1	−3.822295006	9.6969 × 10−249
Cluster 4	Gene Expression	GO Description	Top Gene	logFC	adj. p-Value
	GO:0090304	nucleic acid metabolic process	Set	−1.108981655	1.9585 × 10−289
	GO:0016070	RNA metabolic process	Ddx3x	−1.081698642	3.464 × 10−268
	GO:0016070	RNA metabolic process	Ddx3x	−1.081698642	3.464 × 10−268
	GO:0006139	nucleobase-containing compound metabolic process	Ran	−1.018798075	1.1 × 10−244
	GO:0006396	RNA processing	Tardbp	−1.265502477	5.7847 × 10−261
	GO:0046483	heterocycle metabolic process	Dhx9	−1.062768239	1.0373 × 10−192
	GO:0006725	cellular aromatic compound metabolic process	Gspt1	−1.02188382	1.6288 × 10−189
	GO:0034641	cellular nitrogen compound metabolic process	Mbnl1	−0.97759175	6.1882 × 10−188
	GO:1901360	organic cyclic compound metabolic process	Smc1a	−1.255023232	1.3984 × 10−187
	GO:0034660	ncRNA metabolic process	Rpl11	−0.834339298	5.4663 × 10−171
	GO:0043170	macromolecule metabolic process	Srsf3	−1.232300645	7.5139 × 10−239
Cluster 5	Cell Cycle	GO Description	Top Gene	logFC	adj. p-Value
	GO:0007049	cell cycle	Birc5	−2.60656371	2.1503 × 10−303
	GO:1903047	mitotic cell cycle process	Tgfb1	−1.695288695	5.3792 × 10−306
	GO:0022402	cell cycle process	Prc1	−1.763009143	7.0517 × 10−300
	GO:0006260	DNA replication	Ccdc88a	−1.596474351	1.4062 × 10−302
	GO:0006259	DNA metabolic process	Nasp	−2.48862378	1.2227 × 10−294
	GO:0051301	cell division	Cad	−1.549902684	3.5803 × 10−285
	GO:0051276	chromosome organization	Cenpe	−1.775921663	6.4099 × 10−272
	GO:0010564	regulation of cell cycle process	Ranbp1	−0.391960617	1.1679 × 10−295
	GO:0051983	regulation of chromosome segregation	Racgap1	−1.68593893	8.6581 × 10−262
	GO:0051726	regulation of cell cycle	Cenpf	−2.099842197	1.7343 × 10−268