Table 2.

In vitro studies related to the neuroprotective effects of melatonin in AD. Abbreviations: C6, Rat glial cell; HeLa, Immortal human cell line; N1E-115, Mouse neuroblastoma cell line; PC12, Rat pheochromocytoma cell line; sAPP, Soluble derivates of Amyloid-beta precursor protein; SHSY5Y, Human neuroblastoma cell line; SK-N-SH, Human neuroblastoma cell line; SV770, Monkey kidney cell line; U-138, Human astrocytic cell line.

Study Model	Effects on AD Pathology	References
Multiple cell types (SK-N-SH, SHSY5Y, U-138, SV770, C6, PC12, N1E-115)	Decrease in soluble APP secretion in PC12, SV770, U-138, HeLa, N1E-115	[1]
N2a neuroblastoma cell	Protective effects against tau hyperphosphorylation induced by wortmannin	[77]
N2a neuroblastoma cell	Protective effects against tau hyperphosphorylation induced by calyculin-A	[76]