Figure 1.

Neurod1CKO mutants demonstrate a neonatal diabetic phenotype. (A) Breeding scheme shows genotypes for heterozygous (HET), homozygous mutant Neurod1CKO and control mice. The Isl1^Cre transgene is transmitted paternally to eliminate any potential maternal influence on the developing embryos. (B) The survival of Neurod1CKO embryos is not affected, as shown by chi-squared test. (C) The blood glucose levels of control and Neurod1CKO pups fed ad libitum at P0 and P2-P3. Data are presented as mean ± SD, One-Way ANOVA (**** p < 0.0001).