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. 2021 Jun 29;13(13):3246. doi: 10.3390/cancers13133246

Figure 2.

Figure 2

Germline ERBB2 variants identified via target sequencing. Location of germline variants in the ERBB2 protein identified in cases with a myeloproliferative neoplasm. The amplitude of the “stem” for each germline variant corresponds to its frequency in the cohort. Variants are found throughout the protein, but they spare somatic hotspot regions (dashed lines) including p.S310 and the kinase domain. Extracellular domains are labelled I–IV, and the kinase domain is indicated. # denotes germline variants that have been previously reported in cancer predisposition. aa, amino acids.