Table 7.
Predicted miR-23a-3p targets involved in platinum drug resistance pathway. Reported are TargetScan, microT-CDS scores and Pearson correlations between matched mRNAs and miRNA microarray expression profiles in the Brescia cohort (73 samples: 39 Pt-r, 34 Pt-s) and OVA-BS4 cell line (6 biological replicates: 3 spheroids vs. 3 parental).
| Symbol | Target Scan | microT−CDS | Tarbase | Pearson Correlation | |
|---|---|---|---|---|---|
| Context Score | miTGscore | Experimentally Validated |
Brescia Cohort Microarray |
OVA−BS4 Cell Line Microarray |
|
| APAF1 | −0.54 | 0.96 | Yes | −0.227 | −0.790 |
| BCL2 | −0.36 | 0.73 | No | 0.250 | 0.893 |
| FAS | −0.51 | 0.84 | No | 0.124 | −0.783 |
| PDPK1 | −0.15 | 0.92 | Yes | −0.159 | −0.002 |
| PIK3CB | −0.17 | 0.91 | Yes | 0.040 | −0.201 |
| PIK3R3 | −0.17 | 0.95 | Yes | −0.126 | 0.927 |
| XIAP | −0.28 | 0.95 | No | 0.052 | −0.907 |
| MAP3K5 | −0.08 | 0.81 | No | −0.038 | 0.816 |
Highlighted in bold: anti-correlated genes (<−0.1) in both considered datasets.