Table 2.
Diagnostic performance of White Light Imaging (WLI) and Narrow Band Imaging (NBI) using different classifications for the detection of high-risk leukoplakia.
| Endoscopic Light Imaging. | Clinical Classification | Proposed Cut-Off Point | AUC (95% CI) | Youden’s Index | Accuracy % |
Sensitivity % |
Specificity % |
PPV % |
NPV % |
|---|---|---|---|---|---|---|---|---|---|
| WLI | two-tier classification | 2 | 0.734 (0.675; 0.793) |
0.47 | 72.0 | 78.9 | 67.9 | 58.9 | 84.7 |
| three-tier classification acc. to Chen 2019 | 2 | 0.806 (0.751; 0.861) |
0.46 | 70.9 | 81.7 | 64.7 | 57.4 | 85.8 | |
| 3 | 0.806 (0.751; 0.861) |
0.53 | 80.4 | 60.6 | 92.0 | 81.5 | 80.0 | ||
| NBI | ELS classification | 2 | 0.787 (0.729; 0.844) |
0.57 | 80.1 | 73.4 | 84.0 | 72.7 | 84.4 |
| Ni 2011 classification |
4 | 0.856 (0.809; 0.902) |
0.56 | 77.4 | 81.7 | 74.9 | 65.4 | 87.5 | |
| 5 | 0.856 (0.809; 0.902) |
0.59 | 83.1 | 65.1 | 93.6 | 85.5 | 82.2 | ||
| Ni 2019 classification |
4 | 0.869 (0.826; 0.912) |
0.61 | 80.7 | 79.8 | 81.3 | 71.3 | 87.4 | |
| 5 | 0.869 (0.826; 0.912) |
0.62 | 84.1 | 68.8 | 93.0 | 85.2 | 83.7 |