Table 2.
Age-dependent changes of lesions and symptoms in TSC.
| Lesion/Symptom | Pathology | Age of Occurrence or Worsening | Department in Charge | Note |
|---|---|---|---|---|
| Cardiac rhabdomyoma | Tumor | Fetal–neonatal period | Pediatric cardiology | Spontaneous regression in infancy |
| Cortical tuber | Dysplasia | Fetal–neonatal period/Infancy | Pediatric neurology | Focus of epileptic seizures |
| Hypopigmented macule | Dysplasia | Fetal–neonatal period/Infancy | Dermatology | |
| Epilepsy | Brain dysfunction | Infancy/Childhood | Pediatric neurology | Intractable in many cases |
| ID/ASD | Brain dysfunction | Infancy/Childhood | Pediatric neurology/Psychiatry | |
| Retinal hamartoma | Tumor | Infancy/Childhood | Ophthalmology | |
| Renal cyst | Dysplasia | Infancy/Childhood | Pediatrics | |
| SEGA | Tumor | Childhood/Adolescence | Neurosurgery | Hydrocephalus, potentially fatal |
| Facial angiofibroma | Tumor | Childhood/Adolescence | Dermatology | |
| TAND | Brain dysfunction | Childhood/Adolescence | Pediatrics/Psychiatry | |
| Renal AML | Tumor | Childhood/Adolescence/Adulthood | Pediatrics/Urology | Hemorrhage, potentially fatal |
| Pulmonary LAM | Tumor | Adolescence/Adulthood | Pulmonology | Predominantly affecting women, potentially fatal |