Table 1.
Recognized factors with prognostic significance for treatment stratification.
| COG | SIOP |
|---|---|
| Tumor stage | Tumor stage (before and after pre-operative chemotherapy) |
| Tumor histology | Tumor histology |
| Tumor weight after upfront nephrectomy | Tumor volume after pre-operative chemotherapy |
| Patient age | Lung nodule response (stage IV) |
| Lung nodule response (stage IV) | |
| LOH of chromosome arm 1p and 16q | |
| Gain of chromosome arm 1q 1 | |
| LOH of chromosome arm 11p15 (in VLRWT only) 1 |
1 Validated, but not yet used in prospective risk stratification in published COG trials. Abbreviations: LOH, Loss of heterozygosity; VLRWT, Very low risk Wilms tumor (i.e., age at diagnosis < 2 years, tumor stage I, non-anaplastic histology and tumor weight < 550 g).