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. 2021 Jun 25;22(13):6822. doi: 10.3390/ijms22136822

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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miRNA profiles in plasma-derived sEVs. Fold-change of miRNAs in sEVs derived from blood plasma of scrapie sheep (blue circles) compared with control sheep (black squares) as measured by qPCR. Nine miRNAs were found at detectable levels. Significantly increased levels were found for miR-21-5p (p < 0.05). Data are expressed as a relative expression value after 2^−ΔΔCt conversion using the mean of healthy control sheep as a calibrator, +/− standard deviation (SD). Statistical significance was assessed by Student’s t-test (* p < 0.05). The Exiqon kit was used for sEVs purification.