Table 2.
* Paclitaxel, Docetaxel, Vinflunine. ° Selected regimen collective, treated with 8 mg of Erd continuously. ∆ Pooled data, all patients with prior CPI therapy treated with 1.25 mg EV/kg body weight available for response evaluation. ▼ Estimated using the plots of Kaplan-Meier. π n = 33 [40] + 55 [41] + 117 [42]. ▯ n = 74 [40] + 125 [41] + 301 [42]. ± n = 89 [40] + 125 [41] + 301 [42].
| Medication | CT * [42] | D ± R [43] | Erd ° [44] | EV ∆ [40,41,42] | SG [45,46] | |
|---|---|---|---|---|---|---|
| D + R | D + P | |||||
| Number of CPI pretreated patients (n) | 296 | 17 | 28 | 22 | 74 + 125 + 288 | 17 |
| ORR (%) (95% CI) | 17.9 (13.7; 22.8) | 29.4 | 7.1 | 59.0 | 42.1 (37.8; 46.5) | 23.5 |
| CR (%) (95% CI) | 2.7 | 0 | 0 | NA | 8.5 (4.6; 15.1) | NA |
| PR (%) (95% CI) | 15.2 | 29.4 | 7.1 | NA | 34.5 (30.4; 38.9) | NA |
| SD (%) (95% CI) | 35.5 | 35.3 | 57.1 | NA | 31.3 (27.3; 35.5) | NA |
| PD (%) (95% CI) | 28.0 | 17.6 | 25.0 | NA | 16.7 (13.6; 20.3) | NA |
| Median DoR in months | 8.1 (5.7; 9.6) | NA | NA | NA | 7.5 ▼,π | NA |
| Median PFS in months (95% CI) | 3.7 (3.5; 3.9) | NA | NA | NA | 5.9 (5.4; 6.6) ▼,▯ | NA |
| Median OS in months | 9.0 (8.1; 10.7) | NA | NA | NA | 12.8, ▼,± | NA |