Table 1.

Main players of JAK2/STAT5 signaling cascade.

Gene	Gene ID	Protein Name	Mechanism	Reference
JAK2	3717	Tyrosine-protein kinase JAK2	EPORactivation	[16]
STAT5A	20850	Signal transducer and activator of transcription 5A	Signal transduction and activation of transcription of genes of erythroid differentiation	[5]
STAT5B	6777	Signal transducer and activator of transcription 5B
LYN	4067	Tyrosine-protein kinase Lyn	Phosphorylation/activation of STAT5 Phosphorylation/activation of CRKL	[13]
SRC	6714	Proto-oncogene tyrosine-protein kinase Src	Phosphorylation/activation of STAT5	[11]
FYN	2534	Tyrosine-protein kinase Fyn	Phosphorylation/activation of STAT5	[17]
CRKL	1399	CRK-Like protein	Phosphorylation/activation of STAT5	[14,18]
PTPN18	26469	Tyrosine-protein phosphatase non-receptor type 18	Activation of STAT5	[15]
KPNA4	3840	Importin subunit alpha-3	Nuclear import/export	[9,19]
KPNB1	3837	Importin subunit beta-1
XPO1	7514	Exportin-1 (CRM1)
GATA1	2623	Erythroid transcription factor	Regulation of STAT5 target gene transcription Transcription factor	[20]
KLF1	10661	Krueppel-like factor 1	Regulation of STAT5 target gene transcription Transcription factor	[20]
TAL1 (SCL)	6886	T-cell acute lymphocytic leukemia protein1	Regulation of STAT5 target gene transcription Transcription factor STAT5 target gene	[21]
BCL2L1	598	Bcl-2-like protein 1 (apoptosis regulator Bcl-X)	STAT5 target gene	[20]
CLINT1	9685	Clathrin interactor 1 (EPSINR)	STAT5 target gene EPOR internalization & negative feedback for EPO-induced signaling	[20]
CISH	1154	Cytokine-inducible SH2-containing protein	STAT5 target gene Inhibition of STAT5 signaling Degradation of EPOR	[20,22,23]
SOCS1	8651	Suppressor of cytokine signaling 1	STAT5 target gene JAK2 degradation Inhibitor of EPO signaling/Inhibition of STAT5 signaling	[22]
SOCS2	8835	Suppressor of cytokine signaling 2	STAT5 target gene Inhibition of STAT5 signaling	[22]