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Structures of sterically hindered phenol containing quaternary ammonium moiety (SHP-s-R), where s = 2, 3; R=CH2Ph (SHP-2-Bn); R=CnH2n+1, n = 8, 10, 12, 16 (SHP-2-R) (A); Section of rat cerebral cortex (B); Determination of brain AChE inhibition level in vivo (C) after intranasal administration of PC/SHP-2-Bn/SHP-2-16 nanoparticles. * p = 0.028 and ** p = 0.004 indicate differences by Mann–Whitney test. Reprinted with permission from [40]. Copyright 2020 Royal Society of Chemistry.
