Table 1.
SCD50 and TER values for FaDu and SAS spheroids pre-exposed to different HT doses directly before irradiation. The data were extracted from the SCP curve fittings using function (1), shown in Figure 2c. All treatment-related changes in SCD50 are significant at a level of p << 0.001 (see Materials and Methods for details on statistics using the pooled data sets from N = 2 independent experiments and Table S4 for interexperimental reproducibility of the TER values).
| Spheroid Type | Readout | RT Only | HT + RT | |||
|---|---|---|---|---|---|---|
| 42.5 °C 30 min |
42.5 °C 60 min |
44.5 °C 30 min |
46.5 °C 30 min |
|||
| FaDu | SCD50 (Gy) | 11.1 | 8.7 | 7.3 | 7.5 | 3.2 |
| 95% CI (Gy) | 10.8–11.3 | 8.4–9.1 | 7.1–7.6 | 7.3–7.8 | 3.0–3.6 | |
| TER | 1.3 | 1.5 | 1.5 | 3.4 | ||
| 95% CI | 1.2–1.3 | 1.4–1.6 | 1.4–1.5 | 3.1–3.8 | ||
| SAS | SCD50 (Gy) | 16.5 | 12.4 | 10.2 | 8.0 | 3.5 |
| 95% CI (Gy) | 16.2–16.8 | 12.2–12.7 | 9.9–10.5 | 7.7–8.3 | 3.3–3.9 | |
| TER | 1.3 | 1.6 | 2.1 | 4.6 | ||
| 95% CI | 1.3–1.4 | 1.6–1.7 | 2.0–2.1 | 4.3–5.0 | ||