Table 3.
Main altered functional categories in EC-anaphylaxis compared to EC-control system.
| Category | Subcategory | Zc A | Zc C | Δ Zc | - log (p) |
|---|---|---|---|---|---|
|
Complement
System |
Complement component | 12.72 | -14.33 | 27.05 | 1.82 |
| Complement component 5 | 7.83 | -11.17 | 19.00 | 1.67 | |
| Complement component-related SUSHI domain-containing | 10.86 | -10.03 | 20.89 | 1.87 | |
| Related to G Protein | GNAS complex locus | 0.98 | -1.05 | 2.04 | 1.7 |
| Rap1 complex | -1.17 | 1.01 | -2.18 | -2.17 | |
| Receptors | 5HT2 type receptor mediated signaling pathway | 0.91 | -1.01 | 1.92 | 2.16 |
| Histamine H2 receptor mediated signaling pathway | 0.69 | -0.87 | 1.56 | 1.78 | |
| Thyrotropin-releasing hormone receptor signaling pathway | 1.00 | -0.93 | 1.94 | 2.3 | |
| Tlr 1/2 | -0.78 | 1.12 | -1.90 | -1.78 | |
| Cytoskeleton | Kinesin transport | -0.81 | 0.93 | -1.74 | -2.46 |
| TCR actin (T cell receptor) | -0.93 | 1.10 | -2.03 | -2.38 | |
| DRG1 complex | -1.01 | 1.36 | -2.38 | -1.95 | |
| Actin binding motor protein | -1.47 | 1.23 | -2.70 | -2.55 | |
| Myosin | -1.46 | 1.29 | -2.75 | -3.36 | |
| Cell Signaling | JAK-STAT cascade | -0.85 | 0.65 | -1.50 | -2.08 |
| STAT1 complex | -0.81 | 0.99 | -1.80 | -1.54 | |
| Cell proliferation | -0.82 | 1.20 | -2.02 | -2.47 | |
| Cytotoxicity of leukocytes | -0.85 | 1.21 | -2.06 | -2.57 | |
| Interferon | -1.36 | 1.33 | -2.69 | -1.72 | |
| Interferon-mediated immunity | -1.32 | 1.50 | -2.82 | -1.77 | |
| Enzymes | Glycosidase | 1.02 | -1.19 | 2.21 | 2.06 |
| Kinase inhibitor | 0.77 | -1.02 | 1.79 | 2.24 | |
| Phospholipases | 0.37 | -1.26 | 1.63 | 1.95 | |
| Lymphocyte-specific protein tyrosine kinase | 0.77 | -0.89 | 1.66 | 1.82 | |
| tRNA ligase | -0.85 | 0.94 | -1.79 | -2.37 | |
| Multisynthetase complex | -0.74 | 0.90 | -1.64 | -2.72 | |
| Kinase maturation complex 1 | -1.04 | 1.37 | -2.41 | -1.77 | |
| PTMs | Ubiquitin-conjugatin enzyme E2 | 1.05 | -1.10 | 2.15 | 2.43 |
| Sumo1 complex | -0.79 | 0.82 | -1.61 | -1.84 | |
| E3 ubiquitin ligase | -0.99 | 0.96 | -1.95 | -3.54 | |
| Nuclear/DNA | Set1A complex | 0.84 | -1.06 | 1.90 | 2.17 |
| CSA-POLIIa complex | -0.76 | 0.84 | -1.60 | -1.75 | |
| TERF2-RAP1 complex | -0.94 | 0.71 | -1.65 | -1.54 | |
| H2AX complex I | -0.67 | 1.03 | -1.70 | -1.61 | |
| U5 snRNP complex | -0.81 | 0.91 | -1.71 | -1.75 | |
| DDB2 complex | -0.79 | 0.95 | -1.74 | -1.64 | |
| Other nucleic acid binding | -1.05 | 0.83 | -1.88 | -2.13 | |
| TRBP containing complex | -0.99 | 1.00 | -2.00 | -1.98 | |
| XRCC5 complex | -0.97 | 1.19 | -2.16 | -1.66 | |
| Cell cycle: G2-M DNA damage checkpoint regulation | -0.94 | 1.34 | -2.28 | -1.91 | |
| SNW1 complex | -0.79 | 1.50 | -2.29 | -1.82 | |
| NCOA6-DNA-PK-Ku-PARP1 complex | -1.22 | 1.17 | -2.40 | -1.68 | |
| DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex | -1.21 | 1.31 | -2.52 | -1.92 | |
| DNA repair | -1.32 | 1.45 | -2.77 | -2.39 | |
| TLE1 corepressor complex | -1.58 | 2.05 | -3.63 | -2.85 | |
| Other | Other extracelular matrix | 2.13 | -4.19 | 6.32 | 1.78 |
| Affects N-acetylglucosamine metabolism | 0.98 | -1.12 | 2.10 | 2.19 | |
| Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | 0.51 | -1.14 | 1.65 | 2.9 | |
| nNOS signaling in skeletal muscle cells | -0.75 | 0.76 | -1.51 | -2.66 | |
| Renal glomerulus panel | -0.79 | 0.90 | -1.70 | -2.1 | |
| Increase glucosa metabolism | -0.82 | 0.94 | -1.76 | -1.83 | |
| Hearing | -0.79 | 0.97 | -1.77 | -1.63 | |
| Phagocytosis | -0.88 | 1.01 | -1.89 | -2.08 | |
| De novo purine biosynthesis | -0.91 | 1.06 | -1.97 | -1.63 | |
| Signal recognition particle | -1.04 | 1.00 | -2.04 | -1.58 | |
| Hematopoiesis | -0.85 | 1.45 | -2.30 | -1.51 | |
| Asthma | -1.37 | 0.99 | -2.37 | -2.21 |
The color represents the values of abundance increase (red) or decrease (blue) grouped in functional categories (Zc) using as selection criteria (|ΔZc|> 1.5) and Student’s t test with logarithmic transformation (|-log (p) | ≥ 1.5). Zc A, average of the Zc values in the EC-anaphylaxis group; Zc C, average of the Zc values in EC-control group.