Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 24;12:669162. doi: 10.3389/fimmu.2021.669162

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Saisorn, Saithong, Phuengmaung, Udompornpitak, Bhunyakarnjanarat, Visitchanakun, Chareonsappakit, Pisitkun, Chiewchengchol and Leelahavanichkul

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Prominent cytokine production at 4 h through Spleen tyrosine kinase (Syk) and nuclear factor kappa B (NFκB) in neutrophils of lupus prone mice. Responses of Fcgr2b-/- and wild-type (Fcgr2b+/+) neutrophils after activation by phorbol myristate acetate (PMA), a NETs activator, or lipopolysaccharide (LPS), a TLR-4 stimulator, as evaluated in time-points by supernatant cytokines (TNF-α, IL-6 and IL-10) (A–C) and the downstream signals (at 4 h of the stimulation) in gene expression (Syk and NFκB) (D, E) and protein abundances (Syk/phosphorylated-Syk and NFκB/phosphorylated NFκB) with the representative pictures of Western blot analysis (F, G) are demonstrated (independent triplicated experiments were performed).