Table 3.
Chromosomal alterations detected at diagnosis in locally advanced rectal cancer tumors (n = 39), which were associated with the grade of tumor regression (Dworak grade) after RCT was administrated prior to surgery.
| Non-Responders (G0 and G1) (n = 17) |
Partial Responders (G2) (n = 9) |
Responders (G3 and G4) (n = 13) |
q-Value | Total Cases (n = 39) |
|
|---|---|---|---|---|---|
| 1p36.12 | |||||
| Deleted | 7 (39%) | 4 (44%) | 10 (75%) | <0.001 | 21 (54%) |
| 3q22 | |||||
| Deleted | 1 (7%) | 0 (0%) | 0 (0%) | <0.001 | 1 (3%) |
| 7q34 | |||||
| Deleted | 1 (7%) | 1 (11%) | 0 (0%) | <0.001 | 2 (5%) |
| 7q35 | |||||
| Deleted | 4 (22%) | 2 (22%) | 0 (0%) | 0.03 | 6 (15%) |
| 12p11.23 | |||||
| Deleted | 0 (0%) | 0 (0%) | 1 (8%) | 0.04 | 1 (2.5%) |
| 12p13.31 | |||||
| Deleted | 6 (33%) | 0 (0%) | 2 (17%) | 0.03 | 8 (21%) |
| 17q21.31 | |||||
| Deleted | 6 (33%) | 4 (44%) | 8 (58%) | <0.001 | 18 (46%) |
| Amplified | 7 (39%) | 1 (11%) | 8 (58%) | <0.001 | 16 (41%) |
| 20p12 | |||||
| Deleted | 2 (11%) | 4 (44%) | 5 (42%) | 0.001 | 11 (28%) |
| 22q12.1 | |||||
| Deleted | 5 (28%) | 5 (56%) | 9 (67%) | 0.04 | 19 (49%) |
Results expressed as number of cases and percentage between brackets.