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The calculated IC50 values established for the tested compounds toward keratinocytes (HaCaT) and primary fibroblasts’ cell lines.
| IC50 [µg/mL] | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C5-CAR | AHX-CAR | C12-CAR | C16-CAR | C5-DK5 | AHX-DK5 | C12-DK5 | C16-DK5 | C5-CAR-PEG-DK5 | AHX-CAR-PEG-DK5 | C12-CAR-PEG-DK5 | C16-CAR-PEG-DK5 | DK5 | CAR-PEG-DK5 | |
| Keratinocytes | >50 | >50 | >50 | 25 | 35 | >50 | 1 | 5 | >50 | >50 | 10 | 1 | >50 | >50 |
| Fibroblasts | >50 | >50 | >50 | 12.5 | 20 | 50 | 7 | 7 | >50 | >50 | 12.5 | 4 | >50 | 35 |
