Table 2.
Monoamine transporter and receptor binding.
| NET | DAT | SERT | D2 | α1A | α2A | 5-HT1A | 5-HT2A | 5-HT2c | TAAR1rat | TAAR1mouse | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | Ki [μM] | |
| MDMA | >8.7 | >8.5 | >7.5 | >13 | 6.9±1.2 | 4.6±0.1 | 11±2 | 4.6±1.1 | 4.4±0.8 | 0.25±0.01 | 3.1±0.7 |
| HHMA | 0.94±0.14 | 1.9±0.0 | >7.4 | >13 | >9.5 | 1.3±0.1 | >18 | >12 | >5.1 | 3.0±0.3 | >4.4 |
| HMMA | >8.8 | >8.5 | >7.4 | >13 | >9.5 | >4.7 | >18 | >12 | >5.1 | 0.25±0.04 | 0.45±0.05 |
| MDA | >8.8 | >8.5 | >7.4 | >13 | 8.8±0.6 | 2.6±0.1 | 9.0±0.8 | 3.2±0.8 | 4.8±0.4 | 0.22±0.03 | 0.18±0.03 |
| HHA | 0.79±0.30 | 2.9±0.3 | >7.4 | >13 | >9.5 | 2.0±0.4 | >18 | 9.2±1.7 | >5.1 | 1.9±0.4 | 1.4±0.2 |
| HMA | >8.8 | >8.5 | >7.4 | >13 | >9.5 | >4.7 | >18 | >12 | >5.1 | 0.15±0.02 | 0.05±0.02 |
| Methylone | >8.7 | 2.3±0.1 | >7.5 | >13 | >9.5 | >5.0 | >17 | >12 | >14 | >5.0 | >4.7 |
| HHMC | 4.0±1.0 | 7.1 ±0.3 | >7.4 | >13 | >9.5 | >4.7 | >18 | >12 | >5.1 | 2.2±0.1 | >4.4 |
| HMMC | 4.2±1.0 | >8.5 | >7.4 | >13 | >9.5 | >4.7 | >18 | >12 | >5.1 | >5.2 | >4.4 |
| MDC | >8.8 | >8.5 | >7.4 | >13 | >9.5 | >4.7 | >17 | >12 | >5.1 | 4.8±0.5 | 3.5±0.3 |
| MDPV | 0.10±0.01 | 0.011±0.001 | 2.2±0.1 | >13 | >9.5 | >5.0 | 12±2 | >12 | 2.1 ±0.2 | >5.0 | >4.7 |
| HHPV | 0.11±0.01 | 0.023±0.003 | >7.4 | >13 | >9.5 | >4.7 | 4.3±1.6 | >12 | >5.1 | >5.2 | >4.4 |
| HMPV | 6.2±0.7 | 2.0±0.2 | >7.4 | >13 | >9.5 | >4.7 | >17 | >12 | >5.1 | >5.2 | >4.4 |
Ki values are given as mean±SD.