Table 6.
Uni- and multivariate analyses of factor determinants of resectability for ICC hepatic recurrences.
| Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|
| No RLR (n = 51) | RLR (n = 21) | p | OR (95% CI) | p | |
| Age (years), median ± SD | 66 ± 11.3 | 66.5 ± 14.3 | 0.616 | - | |
| Male sex, n (%) | 23 (45.1) | 8 (38.1) | 0.697 | - | |
| Single tumor, n (%) | 29 (56.9) | 14 (66.7) | 0.441 | - | |
| Ca 19.9 preoperative | 52 ± 8300 | 21.9 ± 1500 | 0.453 | ||
| Tumor diameter >50 mm, n (%) | 36 (70.6) | 13 (66.7) | 0.743 | ||
| Major or ext. hepatectomy, n (%) | 44 (86.3) | 6 (28.6) | <0.001 | 12.1 (2.43–60.74) | 0.002 |
| Anatomical resection, n (%) | 45 (88.2) | 19 (90.5) | 1.000 | - | |
| Laparoscopic resection, n (%) | 3 (5.9) | 4 (19) | 0.183 | - | |
| Associated resection, n (%) | 18 (35.3) | 5 (23.8) | 0.342 | ||
| Type of associated resection | |||||
| Biliary, n (%) | 14 (27.5) | 1 (4.8) | 0.052 | ns | |
| Vascular, n (%) | 5 (9.8) | 2 (9.5) | 1.000 | - | |
| Postoperative complications, n (%) | 30 (58.8) | 12 (57.1) | 0.895 | - | |
| Positive lymph node, n (%) | 21 (46.7) | 3 (16.7) | 0.027 | ns | |
| T stage (TNM 8th) | - | ||||
| -T1a, n (%) | 0 | 0 | - | ||
| -T1b, n (%) | 6 (11.8) | 0 | 0.171 | - | |
| -T2, n (%) | 40 (78.4) | 15 (71.4) | 0.143 | - | |
| -T3, n (%) | 5 (9.8) | 5 (23.8) | 0.435 | - | |
| -T4, n (%) | 0 | 1 (4.8) | 0.292 | - | |
| Satellitosis, n (%) | 12 (23.5) | 1 (5) | 0.093 | - | |
| Surgical margin <1 mm, n (%) | 9 (17.6) | 4 (19) | 1.000 | - | |
| G3, n (%) | 30 (58.8) | 11 (52.4) | 0.616 | - | |
| Microscopic vascular infiltration, n (%) | 46 (90.2) | 20 (95.2) | 0.482 | - | |
| Major vascular infiltration, n (%) | 28 (54.9) | 13 (61.9) | 0.585 | - | |
| Adjuvant chemotherapy, n (%) | 22 (43.1) | 6 (28.6) | 0.249 | - | |
| Recurrence ≤12 months, n (%) | 39 (76.5) | 6 (28.6) | <0.001 | 7.4 (1.68–33.16) | 0.008 |