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. 2021 Jun 28;22(13):6959. doi: 10.3390/ijms22136959

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Changes in biological processes in HNDFs upon treatment with TB-CM. (A) The top 10 gene ontology terms of associated biological processes and molecular function from DEGs in TB-CM-treated HNDF cells are represented using a dot plot with adjusted p-value (p < 0.05). GeneRatio is the intersection size/query size, while the dot size represents the intersection size. (B) KEGG pathway analysis showed the significantly correlated biological pathways in the results of RNA-seq upon treatment of HNDFs with TB-CM during scratch wound migration. (C) The representative upregulated CXCL-related genes, namely CXCL1, CXCL6, CXCL8, CXCL10, and CXCL11, in TB-CM-treated HNDFs were confirmed using quantitative real-time RT-PCR and compared with the results of RNA-seq.