FIG 4.

Growth dynamics of Pf− and Pf+ strains in direct competition during antibiotic treatment. (A) Pf+ density over Pf− density for 0.1× MIC administered twice a day, for 5 days. Each point corresponds to the median concentrations over the last day of treatment, for a random parameter set, sampled uniformly from ranges given in Table 1. The percentage of runs resulting in higher Pf+ density or Pf− density or the extinction of both strains is given in the top left corner, in that order. (B) Pf+ density over time for 0.1× MIC, administered twice a day, for 5 days. Each gray line corresponds to one random parameter set. (C) Associated Pf− density over time. Corresponding plots are shown in panels D, E, and F and G, H, and I for 20× MIC and 30× MIC, respectively.