FIG 1.

Study design schematic. (A) Measures were collected from four compartments: gut microbiome, peripheral immune, diet questionnaire, and plasma metabolome. These separate compartments can all influence each other and can be influenced by other clinical and demographic characteristics such as HIV and treatment status. (B) Analysis pipeline for the study. First, a metabolic health outcome was determined. Second, informative variables were selected using random forest analysis. Lastly, the relationships between these informative variables and the metabolic health outcome were examined.