Table 3.
Results of neuropsychological assessment depending on the HD stage.
| Variables/HD Stages | All HD | Preclinical | Very Early | Early | Intermediate | Advanced |
|---|---|---|---|---|---|---|
| ± SD | ||||||
| SDMT Correct answers |
21.85 ± 18.66 | 54.50 ± 10.73 | 43.58 ± 12.88 | 25.80 ± 9.70 | 14.75 ± 8.36 | 1.90 ± 5.56 |
| SDMT Incorrect answers |
0.68 ± 1.39 | 0.37 ± 0.47 | 0.91 ± 1.08 | 0.71 ± 1.76 | 1.03 ± 1.63 | 0.15 ± 0.67 |
| VF Correct answers |
11.55 ± 8.23 | 24.85 ± 2.41 | 19.72 ± 5.23 | 12.50 ± 5.72 | 10.06 ± 6.45 | 3.50 ± 4.85 |
| VF Incorrect answers |
0.03 ± 0.18 | 0 ± 0 | 0 ± 0 | 0.04 ± 0.21 | 0.06 ± 0.25 | 0 ± 0 |
| VF Repetitions |
0.68 ± 1.35 | 0.42 ± 0.78 | 0.45 ± 1.50 | 0.86 ± 1.12 | 0.93 ± 1.81 | 0.35 ± 0.74 |
| TF I Correct words |
6.40 ± 5.68 | 16.12 ± 4.35 | 12.25 ± 5.20 | 6.63 ± 3.53 | 4.63 ± 3.65 | 1.40 ± 2.25 |
| TF II Correct words |
8.31 ± 8.09 | 20.75 ± 4.39 | 13.58 ± 5.10 | 8.68 ± 4.40 | 5.50 ± 3.56 | 14.10 ± 11.66 |
| TF III Correct words |
7.05 ± 6.33 | 18.25 ± 5.77 | 13.66 ± 4.73 | 7.63 ± 4.04 | 5.16 ± 3.53 | 0.80 ± 1.50 |
| TF I–III Average number of correct words for 3 tests |
21.38 ± 18.11 | 55.37 ± 12.33 | 39.5 ± 13.20 | 22.95 ± 10.69 | 15.56 ± 2.14 | 3.90 ± 6.87 |
| TF I–III Average number of repetitions for 3 tests |
0.61 ± 1.08 | 0.50 ± 0.84 | 0.58 ± 0.9 | 1.00 ± 1.15 | 0.70 ± 10.52 | 0.15 ± 0.48 |
| TMT part 1 Filling time |
106.76 ± 78.5 | 27.12 ± 8.37 | 37.16 ± 9.30 | 68.31 ± 25.96 | 122.80 ± 66.12 | 203.47 ± 68.91 |
| TMT part 1 Correct answers |
20.43 ± 9.54 | 25 ± 0 | 25 ± 0 | 25 ± 0 | 23.03 ± 6.360 | 6.26 ± 10.84 |
| TMT part 1 Incorrect answers |
0.31 ± 0.96 | 0 ± 0 | 0 ± 0 | 0.22 ± 0.75 | 0.46 ± 1.04 | 0.52 ± 1.42 |
| TMT part 2 Filling time |
169.86 ± 114.43 | 47.62 ± 10.87 | 19.72 ± 5.23 | 149.90 ± 59.84 | 203.43 ± 56.3 | 252.36 ± 181.81 |
| TMT part 2 Correct answers |
18.89 ± 10.19 | 25 ± 0 | 25 ± 0 | 23.81 ± 4.11 | 20.90 ± 7.94 | 3.57 ± 8.55 |
| TMT part 2 Incorrect answers |
0.90 ± 1.72 | 0.12 ± 0.35 | 0.45 ± 1.50 | 1.36 ± 1.91 | 1.40 ± 2.07 | 0.36 ± 1.38 |
| SCNT Correct answers |
36.53 ± 23.96 | 72.25 ± 13.82 | 63.25 ± 6.81 | 44.72 ± 13.87 | 29.46 ± 14.2 | 7.80 ± 10.94 |
| SCNT Incorrect answers |
0.19 ± 0.59 | 0 ± 0 | 0.08 ± 0.28 | 0.36 ± 0.95 | 0.20 ± 0.48 | 0.15 ± 0.48 |
| SCNT Incorrect answers–corrected |
0.58 ± 1.02 | 0.62 ± 0.91 | 0.58 ± 0.79 | 0.50 ± 0.96 | 0.96 ± 1.320 | 0.10 ± 0.44 |
| SWRT Correct answers |
43.03 ± 29.04 | 89.25 ± 8.24 | 72.66 ± 23.96 | 50.22 ± 10.92 | 36.86 ± 17.60 | 7.80 ± 13.02 |
| SWRT Incorrect answers |
0.05 ± 0.22 | 0 ± 0 | 0 ± 0 | 0.09 ± 0.29 | 0.06 ± 0.25 | 0.05 ± 0.22 |
| SWRT Incorrect answers–corrected |
0.13 ± 0.47 | 0 ± 0 | 0.08 ± 0.28 | 0.22 ± 0.75 | 0.13 ± 0.44 | 0.10 ± 0.30 |
| SIT Correct answers |
20.04 ± 15.5 | 46.25 ± 14.36 | 34.83 ± 8.24 | 23.63 ± 6.98 | 16.03 ± 10.19 | 2.55 ± 5.28 |
| SIT Incorrect answers |
0.52 ± 1.09 | 0 ± 0 | 0.58 ± 0.99 | 0.86 ± 1.24 | 0.72 ± 1.38 | 0.05 ± 0.22 |
| SIT Incorrect answers–corrected |
0.62 ± 1.02 | 0.25 ± 0.46 | 0.75 ± 0.96 | 1.13 ± 1.48 | 0.68 ± 0.89 | 0.05 ± 0.22 |
± SD—mean ± standard deviation, SDMT—Symbol Digit Modalities Test, VF—Verbal Fluency test, TF—Total Fluency test, SCNT—Stroop Color-Naming Test, SWRT—Stroop Word Reading test, SIT—Stroop Interference Test, TMT—Trail Making Test.