Table 1.
GO enrichment analysis for cHL deregulated miRNA target genes.
| GO Analysis of Target Genes of miRNAs Upregulated in cHL | |||
|---|---|---|---|
| Top 3 GO Terms (p < 0.05) | PANTHER Database | STRING Database | DAVID Database |
| 1 | DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981) | DNA-binding transcription factor activity (GO:0003700) | DNA-binding transcription factor activity (GO:0003700) |
| 2 | DNA-binding transcription factor activity (GO:0003700) | molecular function regulator (GO:0098772) | protein binding (GO:0005515) |
| 3 | molecular function regulator (GO:0098772) | transcription regulator activity (GO:0140110) | regulation of transcription, DNA-templated (GO:0006355) |
| GO analysis of target genes of miRNAs downregulated in cHL | |||
| Top 3 GO terms (p < 0.05) | PANTHER database | STRING database | DAVID database |
| 1 | transcription regulatory region sequence-specific DNA binding (GO:0000976) | DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981) | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077) |
| 2 | RNA polymerase II regulatory region DNA binding (GO:0001012) | transcription regulatory region sequence-specific DNA binding (GO:0000976) | neuron migration (GO:0001764) |
| 3 | transcription regulatory region DNA binding (GO:0044212) | RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) | RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) |