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(A) Schematic of the cohesin complex. Cohesin loading and unloading onto chromosomes during cell cycle is dynamic and involves a number of regulators. STAG2 mutations are the most frequent, and inhibition of STAG1 subunit is synthetically lethal with STAG2 mutations. Listed are the cohesin regulators that can be pharmacologically inhibited and their inhibition mainly disrupts cell cycle progression. (B) Cohesin subunit SMC3 acetylation during S phase ensures sister chromatid cohesion.
